Application of High Purity Acetonitrile in Chemical Analysis

Date:2021-7-8     Category:Industry News


Acetonitrile (CH3CN) is a widely used organic chemical raw material. In addition to being used as an extractant for extracting butadiene and isoprene from olefins and paraffins in the petrochemical industry, it is also widely used as an organic Synthetic raw materials for fine chemicals such as synthesis, medicine, pesticides, surfactants, dyes, and mobile phase solvents for thin layer chromatography, paper chromatography, spectroscopy, polarography, and high performance liquid chromatography (HPLC). Recently, it has been used as DNA Synthesis/purification solvents, organic EL material synthesis solvents, cleaning solvents for electronic parts, etc., all have high requirements for the purity of acetonitrile.

Acetonitrile has been used as an organic modifier and solvent for thin-layer chromatography, paper chromatography, spectroscopy and polarographic analysis in recent years. Since pure acetonitrile does not absorb ultraviolet light at 200nm400nm, one of the applications that is being developed is as a solvent for high performance liquid chromatography, so that the sensitivity of the analytical method is as high as ppb. With the popularization of this testing technology, the demand for chromatographically pure acetonitrile is increasing year by year.

Chromatographic acetonitrile refers to the acetonitrile reagent used for chromatographic analysis, chromatographic separation, and chromatographic preparation

In high performance liquid chromatography (HPLC) analysis, the purity and quality of the mobile phase solvent have an important impact on the analysis results and the instrument itself.

Acetonitrile has unique properties that distinguish it from other HPLC solvents (medium elution capacity, strong solubility, clear chromatographic peaks, low viscosity, and low UV absorption background), making it the most commonly used organic mobile phase component.

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